Expression changes of miR-222 and TIMP3 in non-small-cell lung cancer and its clinical significance
LUO Xiang-yu
LUO Wei-min
ZHANG Jun
LIN Chen-yi
GUO Jia-long
Abstract：Objective To observe the expression changes of miR-222 and matrix metalloproteinase inhibitor 3 (TIMP3) in the non-small-cell lung cancer tissues and to investigate its clinical significance.Methods Eighty-eight pa-tients with non-small-cell lung cancer were chosen.The cancer tissues ( observation group) and 48 cases of adjacent normal tissues ( control group) were selected.In situ hybridization and immunohistochemistry were used to detect the expression of miR-222 and TIMP3 in the two groups.The correlations among the miR-222 and TIMP3 as well as the clinicopathological parameters of non-small-cell lung cancer patients were analyzed.Results The positive rate of miR-222 was 67.05%(59/88) in the observation group, and 35.42% (17/48) in the control group, and the difference was statistically significant (χ2 =12.60, P=0.000).The positive rate of TIMP3 was 40.91%(36/88) in the observation group, and 66.67%(32/48) in the control group, and the difference was statistically significant (χ2 =8.24, P=0.004).In the lung cancer tis-sues, the expression of miR-222 was negatively correlated with the expression of TIMP3 (r=-0.09, P=0.006).Signifi-cant difference was found in the miR-222 and TIMP3 expression between the cancer tissues with different clinical stages and lymph node metastasis (all P<0.05).Conclusion The expression of miR-222 is increased and the expression of TIMP3 is decreased in the non-small-cell lung cancer tissues, and both of them may be related with the occurrence and develop-ment of non-small-cell lung cancer.
Keywords：lung neoplasmsnon-small-cell lung cancermicroRNAmiR-222matrix metalloproteinase inhibitor 3
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 51-53 )