Expression changes of YAP and P73 in ovarian cancer and its significance
AN Jin-dan
WANG Hong-wei
WEI Bao-xia
LIU Xiao-mei
YUE Hui
ZHENG Hui-zhe
ZHANG Wei-ting
Abstract：Objective To observe the expression changes of Yes-associated protein ( YAP) and tumor suppressor gene P73 in the ovarian cancer tissues and to investigate the clinical significance.Methods A total of 157 patients with o-varian cancer, 52 patients with borderline ovarian tumor and 37 patients with benign ovarian tumor were selected, and their tumor tissues were obtained during the surgery.The expression of YAP and P73 in each tumor tissues was detected by im-munohistochemical EliVision method, and the relationships of YAP and P73 with the clinical pathological parameters were analyzed.Results The positive rates of YAP expression in the ovarian cancer, borderline tumor and benign tumor tissues were 42.68%, 59.62%and 67.57%, the positive rates of P73 expression were 65.61%, 38.46% and 35.14%.The positive rates of YAP and P73 expression in the ovarian cancer were significantly lower than those in the borderline tumor and benign tumor tissues (all P<0.01).Significant differences were found in the YAP positive expression of ovarian canc-er tissues with different histological types and ascites (all P<0.05).Significant differences were also found in the P73 positive expression of ovarian cancer tissues with different WHO pathological grades, FIGO clinical stage, lymph node me-tastasis and ascites (all P<0.05).YAP expression was not correlated with P73 expression in the ovarian cancer tissues (r=-0.080, P=0.317).Conclusion In the ovarian cancer tissues, the YAP expression is decreased and the P73 ex-pression is increased, and both of them may be involved in the onset and progress of ovarian cancer.
Keywords：ovarian neoplasmsovarian carcinomaYes-associated proteinP73
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 15-17 )