Comparison in clinical characteristics of acute promyelocytic leukemia with three PML/RARA isoforms
WANG Ying
WEI Hui
LIU Bing-cheng
LIN dong
ZHOU Chun-lin
LIU Kai-qi
MI Ying-chang
WANG Jian-xiang
Abstract：Objective To analyze and compare the clinical characteristics of acute promyelocytic leukemia ( APL) with promyelocytic leukemia ( PML)/retinoic acid receptorαgene ( RARA) different isoforms.Methods The clinical data from 108 APL patients in our center from 2010 to 2014 were collected and the PML/RARA different isoforms were ana-lyzed.Results ①The most common PML/RARA subtype was L isoform, which were 67 cases (62.0%), followed by 30 cases of S (27.8%) and 11 cases of V (10.2%) .②The bleeding was less frequently found in V isoform (45.5%) than in L isoform (74.6%) and S isoform (86.7%) (P=0.026).The median fibrinogen level in V isoform (1.98 g/L) was higher than that in L isoform (1.18 g/L) and S isoform (1.05 g/L) (P=0.024).③The prevalence of FLT3/ITD muta-tion was more frequently found in S isoform (26.7%) than in L isoform (7.6%) and V isoform (0%) (P=0.013).The positive rate of CD34 expression was higher in S isoform (24.1%) than in L isoform (6.3%) and V isoform (11.1%) (P=0.046).④The incidences of retinoic acid syndrome in the high risk group, medium risk group and low risk group were 56.3%, 28.8%and 17.5%, respectively (P=0.021).The difference of the incidence of retinoic acid syndrome in three PML/RARA isoforms was not significant (P=0.643).Conclusions The clinical characteristics of three PML/RARA iso-forms were not exactly the same.The most common subtype was L isoform, the lowest incidence of bleeding was found in V isoform, and S isoform was most likely to be accompanied by FLT3/ITD mutation and CD34 expression.
Keywords：leukemiaacute promyelocytic leukemiapromyelocytic leukemia generetinoic acid receptor αgenePML/RARA Isoformsgene mutationFMS-like tyrosine kinase 3internal tandem duplication mutation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 7-10 )