Expression changes and significance of p-ERK1/2 in endometrioid adenocarcinoma
XIN Wei-juan
ZHAO Jing
ZHANG Xiao-yan
ZHOU Qi
WU Qian-yu
Abstract：Objective To explore the expression changes and clinical significance of extracellular signal -regulated ki-nase (p-ERK1/2) in endometrioid adenocarcinoma .Methods The expression of p-ERK1/2 in 22 cases of endometrioid endometrial cancer (EEC), 20 cases of atypical hyperplasia endometria (EAH) and 20 cases of normal endometria was de-tected by immunohistochemical SP method .Results The expression rates of p-ERK1/2 were 30% ( 6/20 ) , 65% ( 13/20) and 45.5%(10/22) in the normal endometria , EAH and EEC.Compared with the normal endometrial , the positive expression rate of p-ERK1/2 in EAH was higher (P=0.030).In EEC, the positive expression rate of p-ERK1/2 was not statistically different with that of normal endometria and EAH (P=0.306, P=0.207).The expression of p-ERK1/2 was not related with clinicopathological parameters (all P>0.05).Conclusions The p-ERK1/2 overexpression in EEC tissue is not increased , which is related to the endometrium from normal to atypical hyperplasia .However , it may not directly take part in the process of endometrial carcinoma .
Keywords：endometrioid adenocarcinomaextracellular signal-regulated kinaseimmunohistochemistry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )