Clinical value of CEA, CA125, CYFRA21-1, NSE and SCC for evaluation of chemotherapy efficacy and progression in patients with non-small-cell lung cancer

XUE Shan; ZHA Qiong-fang; ZHAO Xu-ji; LIU Bin; JIANG Han-dong

doi:10.3969/j.issn.1002-266X.2015.25.003

Abstract：Objective To investigate the clinical value of serum carcinoembryonic antigen (CEA), carbohydrate anti-gen 125 (CA125), cytokeratin fragment 19 (CYFRA21-1), neuron-specific enolase (NSE) and squamous cell carcinoma antigen ( SCC ) for the evaluation of chemotherapy efficacy and progression in patients with non -small-cell lung cancer . Methods A total of 105 patients diagnosed with non-small-cell lung cancer were included in the study , 35 of them inⅠb-Ⅲa stage received postoperative chemotherapy while 70 of them in Ⅲb-Ⅳ stage received chemotherapy .They were grouped according to their chemotherapy effect and pathology .Patients receiving postoperative chemotherapy were divided in the stable group (13 cases of squamous carcinoma , 12 cases of adenocarcinoma ) and relapse and metastasis group (2 cases of squamous carcinoma , 8 cases of adenocarcinoma ) , on the other hand , patients in Ⅲb-Ⅳ stage were divided into the non-progressive group (14 cases of squamous carcinoma , 16 cases of adenocarcinoma ) and progressive group (13 cases of squamous carcinoma,27 cases of adenocarcinoma).The levels of CEA, CA125, CYFRA21-1, NSE and SCC in the serum samples were detected before chemotherapy , in remission, stable state and progression of each patient .The relationships with chemotherapy efficacy , progression , recurrence and metastasis of diseases were investigated .Results During patients with non-small-cell lung cancer in Ⅲb-Ⅳ stage, the CYFRA21-1 level was significantly decreased after chemotherapy in the non-progressive group, while the levels of CA125, CYFRA21-1 and SCC were significantly increased in the progressive patients as compared with those before chemotherapy;in the patients Ⅲb-Ⅳstage, the levels of CEA, CA125, CYFRA21-1 and NSE were significantly decreased after chemotherapy in the non-progressive group , while the levels of CEA and CA125 were significantly increased in the progressive group as compared with those before chemotherapy .During patients with non-small-cell lung cancer in Ⅰb-Ⅲa stage, the levels of CA125 and NSE were significantly decreased after chemo-therapy in patients who received postoperative chemotherapy of the stable group , while the levels of CEA and CYFRA 21-1 were significantly increased in the relapse and metastasis group .All the differences above were statistically significant ( all P<0.05).Conclusion CEA, CA125, CYFRA21-1, NSE and SCC could be used as the sensitive indicators for the eval-uation of chemotherapy efficacy , relapse and metastasis and progression of non-small-cell lung cancer .