Effects of HERG channel blocker cisapride on apoptosis of gastric cancer cells
SHAO Xiao-Dong
ZHANG Yong-Guo
CHEN Jiang
WANG Jin-Ling
GUO Xiao-Zhong
Abstract：Objective To explore the effects of human eag related gene ( HERG) channel blocker cisapride on the apoptosis of gastric cancer cells and the mechanism .Methods After interfereing HERG current by HERG channel bloc-ker, the cell cycle distribution and opoptosis of gastric cancer cells were investigated by flow cytometry .The ultrastructure of gastric cancer cells was observed under transmission electron microscope .Results Cisapride blocked the HERG current in the gastric cancer cells;HERG channel blocker inhibited gastric cancer cells entering into S phage from G 1 phage and in-duced the apoptosis of gastric cancer cells .Typically morphological changes of apoptosis cells were observed under trans-mission electron microscope .Conclusion HERG channel blocker cisapride can inhibit progression of G 1/S and promote the apoptosis of gastric cancer cells .
Keywords：stomach neoplasmshuman eag related genepotassium channelapoptosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 5-7 )