Expression changes and significance of ER, PR and SRC-3 in endometrial tissues of patients with adenomyosis
WANG Qin
LI Yan
TANG Li
LI Zong-heng
Abstract：Objective To observe the expression changes of estrogen receptor (ER), progesterone receptor (PR) and steroid receptor coactivator-3 (SRC-3) in the endometrial tissues of patients with adenomyosis (AM) and to investigate their significance .Methods The expression of ER , PR and SRC-3 was detected by immunohistochemistry and tissue mi-croarray method in the ectopic endometria of 42 AM patients (EE group) and in the normal endometria of 15 patients with hysteromyoma ( NE group) .Results Compared with the NE group , the expression of ER and PR was decreased , and the expression of SRC-3 was increased in the EE group (all P<0.05).The expression of ER, PR and SRC-3 in the prolifera-tive phase of the NE group was higher than that in the secretory phase (all P<0.05).No statistically significant differences were found in ER, PR and SRC-3 of the EE group between the proliferative phase and secretory phase (all P>0.05).In the secretory phase, the ER expression of the EE group was lower than that in the NE group (P<0.05).There was a neg-ative correlation between ER and SRC-3 in the EE group (r=-0.693, P<0.01).Conclusions ER and PR is lowly ex-pressed and SRC-3 is highly expressed in the endometrial tissues of AM patients , and they may be related with the occur-rence and development of AM .
Keywords：adenomyosisectopic endometriumestrogen receptorprogesterone receptorsteroid receptor coactiva-tor-3
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 37-38,39 )