Expression changes and clinical significance of CXCR4 and MMP-9 in ovarian carcinoma

LIU Jing; ZHANG Liu; YANG Yong; LI Chun-yan; GONG Ping; GUO Hua-xiong

doi:10.3969/j.issn.1002-266X.2015.23.004

Abstract：Objective To observe the expression changes of CXC chemokine receptor 4 (CXCR4) and matrix metal-loproteinase 9 ( MMP-9) in ovarian carcinoma tissues, and to investigate their clinical significance.Methods The expres-sion of CXCR4 and MMP-9 in 60 cases of ovarian carcinoma ( group A) , 20 cases of borderline tumor ( group B) and 10 cases of benign tumor ( group C) was examined by immunohistochemical method.The correlation between them and their correlations with the clinicopathological parameters were analyzed.Results The positive expression rates of CXCR4 in the group A, group B and group C were 58.33%(35/60), 20.00%(4/20) and 10.00%(1/10), respectively.There was a statistically significant difference between group A and groups B and C (all P<0.05).The positive expression rates of MMP-9 in the group A, group B and group C were 83.33% (50/60), 35.00%(7/20) and 20.00% (2/10), respec-tively.Significant difference was found when we compared group A with groups B and C (all P<0.05).In ovarian carci-noma, the expression of CXCR4 protein was related with TNM stage and lymph-node metastasis;the expression of MMP-9 protein was related with tumor histological grade, TNM stage and lymph-node metastasis ( all P<0.05) .The CXCR4 ex-pression was positively correlated with the expression of MMP-9 in the ovarian carcinoma tissues (r=0.257, P<0.05). Conclusions The expression of CXCR4 and MMP-9 is increased in the ovarian carcinoma tissues, which may play an im-portant role in the carcinogenesis and development of ovarian carcinoma.The combined detection of CXCR4 and MMP-9 may provide scientific experimental evidence for targeted therapy.