Expression changes of NFKBIA in hepatocellular carcinoma and its significance
WANG Wen-jie
REN Gang
QI Jiu-de
LIU Shi-hai
LIANG Jun
Abstract：Objective To explore the expression changes of NFKBIA in the primary hepatocellular carcinoma ( PHC) tissues and its relationships with the clinicopathological parameters and prognosis.Methods The expression of NFKBIA mRNA in the cancerous tissues and adjacent normal tissues from 74 patients with liver cancer receiving the surgeries was detected by RT-PCR.The expression of AFP, Ki-67 and Connexin-43 in the liver cancer tissues was qualitatively detected by immunohistochemistry.The associations of NFKBIA expression levels with gender, age, diameter of the tumor, differen-tiation, tumor envelop completeness, liver cirrhosis, tumor thrombus and the expression of AFP, Ki-67 and Connexin-43 were analyzed.Mean survival time ( MST) was compared between patients with positive NFKBIA and patients with negative NFKBIA.Results The expression of NFKBIA in the cancer tissues (1.13 ±0.78) was significantly lower than that in the adjacent normal tissues (2.11 ±1.56) (P<0.05).The expression of NFKBIA mRNA in the liver cancer tissues was re-lated with the tumor envelop completeness (P<0.05), and was not related with gender, age, diameter, differentiation, tumor thrombus, liver cirrhosis and the expression of AFP, Ki-67 and Connexin-43 (all P>0.05).The MST of patients with negative NFKFIA expression ( 17 months ) was shorter than that of patients with positive NFKBIA expression ( 22 months), (P<0.05).Conclusion The expression of NFKBIA decreases in the liver cancer tissues, which may be closely related to tumor envelop completeness.The negative NFKBIA expression predicts the poor prognosis of patients with PHC.
Keywords：hepatocellular carcinomaNFKBIA genetumor envelop completeness
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )