Effects of compound rhodiola sachalinensis on microalbuminuria and advanced oxidation protein products of rats with type 2 diabetic nephropathy
LI Ling-huan
YUAN Shao-jing
LIU Jie
WANG Min
LUO Lan
SUI Chen-hui
ZHU Ji-ying
Abstract：Objective To observe the changes of microalbuminuria ( mALB) and advanced oxidation protein products ( AOPPs ) of rats with type 2 diabetic nephropathy ( T2DN) by feeding compound rhodiola sachalinensis ( Fufang Hongjin-tian) and to investigate its mechanism of protecting the kidney.Methods Fifty male 8-week-old Wistar rats were random-ly divided into the normal control group (A group, n=5) and model group (n=45).During the 45 rats, 43 rat models with DN were successfully made.Then, they were randomly divided into the model control group (group B, n=10), low dose compound rhodiola sachalinensis group ( group C) , medium-dose compound rhodiola sachalinensis group ( group D, n=11), and high-dose compound rhodiola sachalinensis group (group E, n=11).Rats in the groups C, D and E were treated by 3, 6 and 12 g/( kg· d) compound rhodiola sachalinensis and rats in the group B was treated by intragastric ad-ministration of the same amount of normal saline for 4 weeks.The FBG, FINS, HOMR-IR, TG, TC, AOPPs and 12-hour mALB level in the caudal vein of rats were detected before and after treatment and the body weight ( BW) was also ob-served.Results Before treatment, the BW of group B was significantly lower than that of group A, but FPG, FINS, HOMR-IR, TG, TC, mALB and AOPPs level was higher than that of group A (P<0.05 or P<0.01).After treatment of 4 weeks, the BW of groups C, D and E was higher than that of group B, but FPG, AOPPs and mALB was lower than that of the group B (all P<0.01).No statistical difference was found in FPG, AOPPs and mALB among groups C, D and E (all P>0.05).Conclusion Compound rhodiola sachalinensis (Fufang Hongjingtian) has the protective effect on kidney of T2DN rats by reducing the levels of mALB and AOPPs.
Keywords：diabetic nephropathycompound rhodiola sachalinensis(Fufang Hongjingtian)urinary microalbuminadvanced oxidation protein productsrats
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 23-25 )