Changes in levels of CyPA and AngII in peripheral blood of patients with acute kidney injury and influence of hemodialysis on them
MENG Hu
ZHOU Xiao-pin
XU Jian
LUO Hui-ming
YUAN Hong-ling
XIONG Li-yan
Abstract：Objective To observe the changes in levels of cyclophilin A ( CyPA) and Angiotensin Ⅱ ( AngⅡ ) in the peripheral blood of patients with acute kidney injury ( AKI) and to investigate the influence of hemodialysis on them. Methods Forty patients with AKI (observation group) were randomly divided into the dialysis group (23 cases) and non-dialysis group (17 cases).All patients received the treatment of irbesartan 150 mg/d for 4 weeks.The peripheral blood was obtained before and after treatment for 4 weeks to determine the levels of CyPA and AngⅡ .Another 40 gender-and age-matched healthy people were selected as the control group.We observed the levels of CyPA and AngⅡin the peripher-al blood of the observation group and control group, dialysis group and non-dialysis group, and analyzed the relationships between changes in levels of CyPA and AngⅡ.Results Before treatment, the levels of CyPA and AngⅡin the peripher-al blood of the observation group were higher than those of the control group (all P<0.01).In the observation group, the levels of CyPA and AngⅡwere decreased after treatment as compared with those before treatment (all P<0.01).In the peripheral blood of AKI patients, the levels of CyPA and AngⅡwere positively correlated (r=0.600, P<0.05).No sig-nificant differences were found in the levels of CyPA and AngⅡbetween dialysis group and non-dialysis group.Conclusion CyPA, as a kind of an inflammatory mediator, may, aggravate the renal tubular epithelial cell injury and apoptosis, and hemodialysis has no effect on CyPA and AngⅡin the peripheral blood of AKI-patients.
Keywords：acute kidney injurycyclophilin AAngiotensinⅡ
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 10-12 )