Expression of Cripto-1 in cervical squamous cell carcinoma and its significance
BAN Zhen-Ying
ZENG Xian-Xu
ZHANG Wei
DANG Qiu-hong
ZHANG Huan-huan
DU Yan-min
Abstract：Objective To observe the expression changes of Cripto-1 in the cervical squamous cell carcinoma and to explore the effects on the tumor occurrence and development process.Methods Immunohistochemistry was used to exam-ine the expression levels of Cripto-1 in 60 cases of cervical squamous cell carcinoma, 60 cases of cervical intraepithelial ne-oplasia and 24 cases of normal cervical epithelia.The correlations of Cripto-1 expression with the clinical pathologic param-eters and the epithelial-mesenchymal transformation ( EMT) markers ( N-cadherin, Vimentin and E-cadherin) were also analyzed.Results The expression levels of Cripto-1 protein were gradually increased in the normal cervical epithelia, cervical intraepithelial neoplasia and cervical squamous cell carcinoma; and significant difference was found among these three groups (all P<0.05).The positive expression rate of Cripto-1 also showed significant differences in the cervical squamous cell carcinoma with or without lymph node metastasis and different clinical stages (all P<0.05).The positive expression of Cripto-1 was positively correlated with N-cadherin and Vimentin (r=0.561, r=0.328, respectively;all P<0.05), while it was negatively correlated with E-cadherin (r=-0.468, P<0.05).Conclusion The expression of Cripto-1 is closely related to the carcinogenesis and development of cervical squamous cell carcinoma, and may promote the invasion and metastasis of carcinoma by up-regulating the Cripto-1 expression to regulate the EMT.
Keywords：uterine cervical neoplasmsCripto-1epithelial-mesenchymal transformation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )