Clinical features of hepatic encephalopathy induced by bacterial infection in patients with hepatitis B virus-related cirrhosis

LIU Hua; HAN Tao; LI Ying

doi:10.3969/j.issn.1002-266X.2015.19.003

Abstract：Objective To analyze the clinical features of hepatic encephalopathy ( HE) induced by bacterial infection in patients with hepatitis B virus ( HBV)-related cirrhosis.Methods A total of 186 cases of patients with HBV-related cirrhosis and HE were divided into the infection group (59 cases) and non-infection group (127 cases) according to wheth-er the presence of bacterial infections.We observed the blood ammonia, serum albumin ( ALB) , alanine aminotransferase ( ALT) , total bilirubin ( TBIL) , international normalized ratio ( INR) , white blood cell ( WBC) , the percentage of neutro-phile granulocyte, serum creatinine ( Cr) and the mortality rate in the two groups.Results In the infection group, ammo-nia was (113.7 ±63.0)μmol/L, ALT was (206.3 ±86.4) U/L, TBIL was (113.7 ±62.9) mmol/L, WBC was (11.0 ±7.3) ×109/L, the percentage of neutrophile granulocyte was 79.6%±6.6%, Cr was (118.2 ±91.4) μmol/L, the Child-Pugh scores were (13 ±1) scores and the mortality rate was 40.6%.In the non-infection group, ammonia was (80.9 ±40.7) μmol/L, ALT was (114.2 ±20.9) U/L, TBIL was (80.9 ±40.7) mmol/L, WBC was (6.6 ±4.8) × 109/L, the percentage of neutrophile granulocyte was 61.4%±6.9%, Cr was (72.9 ±34.3) μmol/L, Child-Pugh scores were (10 ±1) scores and the mortality rate was 28.3%.Significant differences were found in the above indexes between the two groups ( all P<0.05) .Conclusions Serious liver damage is found in patients with HBV-related cirrhosis and HE induced by bacterial infection.Meanwhile, the patients have high ammonia, WBC, the percentage of neutrophile granulo-cyte levels and high mortality rate.