Pharmacokinetics monitoring of EC-MPS in Chinese renal allograft recipients
SHI Tian-ming
YANG Yang
ZHOU Pei-jun
XU Da
WANG Xiang-hui
SHAO Kun
Abstract：Objective To observe the pharmacokinetics features of mycophenolic acid ( MPA) in Chinese renal al-lograft recipients who took Myfortic ( EC-MPS) and to establish a calculation for the abbreviated MPA area under the curve (AUC) of plasma concentration and time .Methods Thirty renal-transplant recipients were treated with EC-MPS (1.44 g/d) in combination with cyclosporine ( CsA) and prednisone ( Pred) .Plasma MPA concentrations were determined by E-MIT method at pre-medication, 0.5, 1, 1.5, 2, 4, 6, 8, 10 and 12 hours (C0.5,C1,C1.5,C2,C4,C6,C8,C10 and C12) af-ter oral administration .The MPA AUC0-12 h were calculated by using the trapezoidal rule and the abbreviated MPA AUC model equation fitted to 30 MPA AUC0-12 h profiles was generated by the multiple regression analysis .Results The phar-macokinetics of EC-MPS in 30 renal-transplant recipients manifested great inter-patient difference . The mean MPA AUC0-12 h was (47.64 ±25.14) mg· h/L.We selected C1.5, and C2 at two different time points and C2, C4, C6 and C8 at four different time points.Then, the abbreviated MPA AUC model equations were recommended:AUC=27.41+0.87 ×C1.5 +0.88 ×C2(r2 =0.67), or AUC=3.98+2.03 ×C2 +2.18 ×C4 +1.91 ×C6 +5.08 ×C8(r2 =0.86);the abso-lute prediction error was (28.8 ±24.8)%and (12.8 ±10.1)%, respectively.In 30 recipients, the absolute prediction error between estimated MPA AUC and full MPAAUC 0-12 h was within ±15%.Conclusions EC-MPS pharmacokinetics in Chinese renal allograft recipients manifests a substantial inter-individual variability .We get the MPA AUC simplified calcu-lation formula, which needs less sampling point and has good predictive effect .
Keywords：kidney transplantationmycophenolic acidpharmacokineticsChinese
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 10-13 )