Expression and correlation of HuR and HIF-1αin hepatocellular carcinoma
LIU Li-ping
JIANG Jian-xin
BAO Shi-yun
ZHANG Yu-sen
HE Wan
Abstract：Objective To investigate the expression and correlation of human antigen R ( HuR) and hypoxia-induc-ible factor (HIF)-1αin hepatocellular carcinoma (HCC) tissues.Methods Forty-eight cases of HCC tissue and adjacent tissue samples were collected from patients undergoing surgical resection .The expression of HuR and HIF-1αprotein in the HCC and adjacent tissues was detected by immunohistochemical staining .The mRNA expression of HIF-1αin the HCC tis-sues was detected by fluorescent quantitative PCR .Results The positive expression rates of HuR and HIF-1αprotein in the HCC tissues were 67%and 58%, respectively .These rates were significantly higher than the positive expression rates of HuR and HIF-1αprotein (19%and 10 %) in the adjacent tissues ( all P<0.01) .The expression of HuR protein was positively correlated with the expression of HIF-1αprotein in the HCC tissues (r=0.723, P<0.01).The mRNA expres-sion of HIF-1αmRNA in the group with high expression of HuR protein was significantly up-regulated as compared with that of the group with low expression of HuR protein (P<0.05).Conclusions The expression of HuR and HIF-1αprotein was up-regulated and positively correlated with each other in the HCC tissues .HuR may enhance the stability of HIF-1αmRNA, and thus increase the expression of HIF-1αprotein.
Keywords：liver carcinomahuman antigen Rhypoxia-inducible factor-1αRNA-binding protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )