Influence of fasting plasma glucose level on mean platelet volume in patients with ischemic stroke and its clinical significance

LYU Li-xia; KAN Peng-cheng

doi:10.3969/j.issn.1002-266X.2015.16.006

Abstract：Objective To observe the influence of fasting plasma glucose ( FPG) level on mean platelet volume (MPV) in patients with ischemic stroke (IS) and to explore its clinical significance .Methods A total of 522 patients with IS (IS group), 115 patients with type 2 diabetes (T2DM group) and 120 normal healthy persons (control group) were enrolled into this study .According to FPG levels , IS patients were divided into four groups: group A including 222 patients (3.89 mmol/L≤FPG<5.0 mmol/L), group B including 105 patients (5.0 mmol/L≤FPG<5.5 mmol/L), group C including 115 patients (5.5 mmol/L≤FPG<6.1 mmol/L) and group D including 80 patients (6.1 mmol/L≤FPG<7.0 mmol/L).Group A and B were the normal FPG group, group C and D were impaired fasting glucose (IFG) ( group C was mild IFG , group D was severe IFG ) .The parameters including FPG , blood lipids , liver and kidney func-tion, and MPV were obtained.Meanwhile, the correlations between MPV and any one of the above parameters were evalua -ted.Results MPV was (8.55 ±0.72), (8.88 ±0.86), (8.92 ±0.90), (9.12 ±0.96), (12.23 ±1.36) and (8.63 ±0.72) fL in the groups A, B, C, D, T2DM and control group, respectively.MPV of the T2DM group was significantly higher than that in any other groups ( all P<0.01).MPV of the groups C and D were higher than that in groups A and B . Moreover, MPV of group D increased more significantly (all P<0.05).MPV in the normal FPG group, IFG group and T2DM group was positively correlated with FPG , age, UA and LDL-C ( P<0.05).Multiple linear regression analysis showed that MPV in each group was independently correlated with FPG (all P<0.05).Conclusion MPV is increased in the IS patients with the increase of FPG , and it is of great significance for the surveillance and prevention of cardiovascular and cerebrovascular disease to pay close attention to MPV and blood glucose changes .