Expression and significance of K17, lFN-γand PCNA in skin lesions of patients with squamous hyperplasia of vulva
LI Juan
LI Zong-heng
TANG Li
LI Yan
CHEN Zhuang
Abstract：Objective To observe the expression levels of the keratin 17 (K17), interferon-γ(IFN-γ) and prolifera-ting cell nuclear antigen ( PCNA) in skin lesions of patients with squamous hyperplasia of vulva , and to explore their signif-icance .Methods Twenty-seven patients with squamous hyperplasia of vulva , the lesions were taken as group A and the normal epidermis surrounding the lesions as the group B .The expression levels of PCNA , K17 and IFN-γwere detected by the immunohistochemical SP method , and the correlations with the squamous hyperplasia of vulva were analyzed . Results The proliferation indexes of group A and group B were 26.24%±6.60% and 10.47%±4.77%, respectively (P<0.01).The average optical density of K17 and IFN-γin the group A was significantly higher than that in the group B (all P<0.01).In the group B, the expression of K17 was not related with the IFN-γexpression (r=0.122,P>0.05).In the group A, the expression of K17 was positively correlated with the IFN-γexpression (r=0.607,P<0.01). Conclusion The increased expression levels of K 17, IFN-γand PNCA in the skin lesions of patients with squamous hy-perplasia of vulva has significantly relevance to its pathogenesis .
Keywords：squamous hyperplasia of vulvakeratin 17interferon-γproliferating cell nuclear antigenimmunohis-tochemistry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 24-26 )