Variation characteristics of retinal thickness and light sensitivity of macular central 10°regions and their correlations in pathological myopia

GUO Hai-xia; CHU Yan-hua; HAN Quan-hong

doi:10.3969/j.issn.1002-266X.2015.12.001

Abstract：Objective To examine the variation of retinal thickness (RT) and light sensitivity (MS) of the macular central 10°regions of pathological myopic eyes , and further to analyze their correlations .Methods Sixty-five pathological myopic eyes of 50 patients without maculopathy were enrolled in this cross-sectional study .All patients underwent spherical equivalent (SE) and axial length (AL) measurement.Then fast macular thickness procedure of Cirrus HD-OCT was used to evaluate the RT of macular region .We only reserved the central 5 regions and recorded the RT of superior , temporal, in-ferior, nasal and central quadrant (RTs, RTt, RTi, RTn, RTc).Then the mean light sensitivity (MSw) was recorded a-mong all myopia eyes by using MAIA microperimetry .We divided the macular central 10°regions into 5 parts.The mean light sensitivity of each part (MSs, MSt, MSn, MSi, MSc) were also determined.The correlation between SE and AL, the correlation between RT and MS of corresponding part , the correlation between RT , MS and SE, AL were all analyzed .Re-sults Significant difference of RT in each section of central macular region was revealed by OCT test ( F=58.409, P=0.000).No significant difference of MS in each section of macular region was found (F=0.406, P=0.801).SE was negatively correlated with AL (r=-0.838, P=0.000).There was a positive correlation between RTs and SE (r =0.390, P=0.025), a negative correlation between RTs and AL (r=0.391, P=0.033), a negative correlation between RTn and AL (r=0.382, P=0.037).MSw was positively correlated with MS and SE (rw =0.329, P=0.029; rs =0.304, P=0.045;rt=0.323, P=0.033; ri =0.323, P=0.033; rn =0.325, P=0.031; rc =0.316, P=0.036). But no correlation was found between MS and AL .In the superior , inferior and nasal region , we also found a positive corre-lation between retinal thickness and light sensitivity (rs =0.420, P=0.019; ri =0.365, P=0.020; rn =0.381, P=0.013).Conclusions The macular retinal thickness distribution had disparity in the macular central 10°regions of patho-logical myopia .As the AL of eye increased , the RT at certain sections decreased .As the SE increased , all regions had a decreasing MS .