Expression changes and clinical significance of RhoC and CD105 proteins in gastric adenocarcinoma
XIAO Xing-guo
Abstract：Objective To investigate the expression changes of RhoC and CD 105 proteins in gastric carcinoma tissues and to study their significance .Methods The expression of RhoC and CD 105 proteins was detected by immunohistochemis-try in the normal gastric mucosa tissues (n=30), gastric hyperplasia tissues (n=40) and gastric carcinoma tissues (n=108).The correlations between RhoC and CD 105 protein[microvessel density (MVD)], and with the clinic pathological parameters were all studied .Results The positive expression rates of RhoC in the groups of normal gastric mucosa , gastric hyperplasia and gastric carcinoma were 26.7%, 60.0%and 86.1%, respectively (all P<0.01).The MVD indexes in the groups of normal gastric mucosa , gastric hyperplasia and gastric carcinoma were 10.76 ±1.96, 12.03 ±1.32 and 32.63 ±3.79 (all P<0.01).The protein expression of RhoC was related with the clinical stages , depth of tumor infiltra-tion and lymph node metastasis of the gastric adenocarcinoma;CD105 was related with the differentiated degree , clinical sta-ges, depth of tumor infiltration and lymph node metastasis of the gastric adenocarcinoma cells (all P<0.05).The MVD was higher in the positive group about the expression of RhoC protein than that in the negative group .Conclusions The high expression of RhoC participates the tumor infiltration and lymph node metastasis of gastric adenocarcinoma tissues , and RhoC is likely to promote angiogenesis in gastric carcinoma .The combined detection of RhoC and CD 105 is helpful to the di-agnosis of gastric adenocarcinoma .RhoC protein may be used as one of the important biological markers in the diagnosis of gastric carcinoma .
Keywords：gastric neoplasmsgastric carcinomaRas homologue Cmicrovessel density
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 21-23 )