Expression changes of Mfn2 in infiltrating ductal carcinoma of breast and the clinical significance
XIE Yan-li
JIAO Jun-qin
LIU Yue-ping
MA Li
Abstract：Objective To observe the expression changes of mitofusin 2 ( Mfn2 ) in infiltrating ductal carcinoma of breast and to investigate its clinical significance .Methods The immunohistochemical SP method was used to assess the expression of Mfn2 in 116 cases of infiltrating ductal carcinoma of breast ( observation group ) and 10 cases of normal breast ductal epithelial tissues (control group).The relationships between Mfn2 expression and the clinicopathological parameters of breast infiltrating ductal carcinoma patients were analyzed .Results The positive expression rates of Mfn 2 in the obser-vation and control groups were 44.82%(52/116) and 90.00%(9/10), respectively (all P<0.05).The Mfn2 expres-sion was related with lymph node metastasis, histological grade, TNM staging, estrogen receptor, progesterone receptor and epidermal growth factor receptor-2 of breast infiltrating ductal carcinoma (all P<0.05).Conclusion The Mfn2 expres-sion is decreased in the breast infiltrating ductal carcinoma tissues , which may play an important role in the occurrence and development of infiltrating ductal carcinoma of breast.
Keywords：breast neoplasmsinfiltrating ductal carcinoma of breastmitofusin 2
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-20 )