Application of 99m Tc-MDP bone scanning in diagnosis of breast cancer with bone metastasis

XU Shou-lin; FENG Xue-feng

doi:10.3969/j.issn.1002-266X.2015.11.005

Abstract：Objective To observe application effect of 99m Tc-MDP bone scanning in the diagnosis of breast cancer with bone metastasis.Methods 99mTc-MDP bone scanning of the whole body was performed in 317 cases of patients with breast cancer.A week before 99mTc-MDP bone scanning, fasting venous blood was collected (3.0 mL), and then, the serum carci-noembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and carbohydrate antigen 15-3 (CA15-3) was detected by using the ECL assay .The relationships between serum CEA , CA125, CA15-3 and bone scanning were analyzed by ROC curve, and we calculated CUT-OFF value of CEA, CA125, CA15-3 in diagnosis of breast cancer with bone metastasis .Re-sults 99mTc-MDP bone scanning showed there were 245 cases of patients without bone metastasis (negative), and 72 cases of bone metastasis (positive, 52 cases of gradeⅠ, 20 cases of gradeⅡand above).Compared with the negative bone scanning , the levels of CEA, CA125 and CA15-3 were increased in the patients of bone scanning gradeⅠ,Ⅱand above (all P<0.05);compared with gradeⅠbone scanning , the levels of CEA , CA125 and CA15-3 were increased in patients of bone scanning gradeⅡ(all P<0.05).99mTc-MDP bone scanning showed when the bone scanning reached grade Ⅱand above, the area under the ROC curve of serum CEA , CA125 and CA15-3 was 0.80, 0.98 and 0.88, respectively .The CUT-OFF values of CEA , CA125 and CA15-3 in diagnosis of breast cancer with bone metastasis were 22.35, 38.71 and 41.96 U/mL.Conclusions 99m Tc-MDP bone scanning can be used as a diagnostic tool in the breast cancer with bone metastases screening .When the serum CEA, CA125 and CA15-3 levels are above 22.35, 38.71 and 41.96 U/mL, we should be more vigilant about the oc-currence of multiple bone metastases, which needs for the 99mTc-MDP bone scanning.