Regulation function of total hedysari polysaccharide in sweeping away free radicals and antioxidant capacity on aging rats
LEI Feng-feng
YUE Shu-qin
SUN Li-gang
ZHANG Chang-qing
SANG Ying-zhu
Abstract：Objective To observe the regulation function of total hedysari polysaccharide ( THPS) in sweeping away free radicals and antioxidant capacity on aging rats .Methods Seventy-two Wistar rats were randomly divided into groups A, B, C, D, E and F.Every group had 12 rats.The aging models were made in groups A , B, C, D and E.and group F was the control group .On the next day of modeling , rats in the groups A , B, C and D were intraperitoneally injected with THPS 50, 100, 200 and 400 mg/kg every day respectively for 30 days.Rats in groups E and F were intraperitoneally injec-ted with 10 mL/kg normal saline everyday for 30 days.The scavenging rate of superoxide anion free radical (O·-2 ) and the hydroxyl free radical ( OH-· ) in each group was detected .The content of malondialdehyde ( MDA) , the activities of su-peroxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in the blood serum and hepatic tissues were detected . Results Compared with group E , the scavenging rates of O ·-2 and OH-· were higher in groups A , B, C and D ( all P<0.05);the content of MDA in the blood serum was decreased and the activity of GSH-PX in the blood serum was higher in the group B (all P<0.05);in the blood serum and hepatic tissues, the content of MDA was all decreased and the activi-ties of SOD and GSH-PX were increased in groups C and D (all P<0.05).Conclusion THPS can sweep away the con-tent of O ·-2 and OH -· , decreases MDA in the blood serum and hepatic tissue homogenate , and increases the activities of SOD and GSH-PX in the blood serum and hepatic tissue homogenate .
Keywords：total hedysari polysaccharideagingsuperoxide dismutaseglutathione peroxidasemalondialdehyde
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )