Expression changes and significance of p11 mRNA in peripheral blood mononuclear cells of patients with post-traumatic stress disorder
LI Zhe
ZHANG Zhi-qiang
QI Ming
ZHANG Gui-qing
Abstract：Objective To investigate the expression changes and significance of p 11 mRNA in the peripheral blood mononuclear cells (PBMCs) of patients with post-traumatic stress disorder (PTSD).Methods In the PTSD group, there were 19 cases of patients;during the 19 patients, 13 cases of patients (who were taken as the non-PTSD group) did not de-veloped into PTSD;another 19 cases of healthy people were selected as the control group .The mRNA expression levels of p11 of all participants were estimated by using real-time fluorescence quantitative polymerase chain reaction .Post-traumatic stress disorder check-list-civilian version ( PCL-C), Hamilton Anxiety Scale ( HAMA) and Hamilton Depression Scale ( HAMD) were used to access the condition of patients .Pearson correlation analysis was used to analyze the correlations of p11 mRNA expression with HAMA, HAMD and PCL-C scores.Results The relative expression of p11 mRNA in the PTSD group, non-PTSD group and control group was -0.495 ±0.920, 0.911 ±1.474 and -0.000 ±0.791, respective-ly.The PTSD group and control group showed a significant difference as compared with the non -PTSD group ( all P<0.05).The scores of HAMA, HAMD and PCL-C in the PTSD group were (21.63 ±7.79), (25.11 ±8.56) and (55.84 ±6.35), respectively.In the non-PTSD group, the scores were (10.31 ±6.22), (13.00 ±9.88) and (31.77 ±5.09), respectively.Multiple comparison showed there were significant differences between these two groups (all P<0.05).In the PBMCs, the relative expression of p11 mRNA was negatively correlated with HAMD (r=-0.299, P=0.033), was negatively correlated with PCL-C (r=-0.385, P=0.030), and was not related with HAMA (r=-0.233, P=0.111). Conclusion The p11 mRNA expression level is decreased , which may help in the diagnosis and differential diagnosis of PTSD and non-PTSD.
Keywords：traumastress disordersperipheral blood mononuclear cellsp11 gene
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )