Effect of polyacrylamide gel as embolic agent in rabbit hepatic arterial embolism

WEI Jia-liang; MENG Zhi-bin; FAN Li-wei; MA Yi-long; OU Sheng-qiu; ZHAO Chang

doi:10.3969/j.issn.1002-266X.2015.10.008

Abstract：Objective To observe the effect of polyacrylamide ( PAM) gel as the embolic agent in rabbit hepatic arte-rial embolism.Methods Fifteen rabbits were selected , and PAM gel was injected into the right femoral artery-hepatic ar-tery via microcatheter .Hepatic artery embolization was observed by radiography .On preoperative 1 d and postoperative 1 d, 3 d and 7d, the changes of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the periph-eral venous blood was detected .On postoperative 3, 7 and 14 d, we dissect two from each group , took out the liver to gen-erally observe the situation of liver surface and prepared sliced of HE staining to observed pathological changes after emboli -zation under an optical microscope .Results During the operation , the injection process of embolic agents was smooth , and no microcatheter jammed .After embolism, angiography showed that small hepatic artery and its branches , peripheral artery were undeveloped.On postoperative 1 and 3 d, ALT and AST were higher than that before operation (all P<0.05). On postoperative 3 and 7 d, ALT and AST were much lower than that on postoperative 1 d (all P<0.05).The inflamma-tion was evident at liver surrounding connective tissues , inflammatory cell infiltrated liver sinusoids and portal area with thrombosis after embolization .Conclusion PAM gel as an embolic agent for rabbit hepatic artery has exact effect .It can completely embolize objective liver tissues , and has a little damage to liver functions .Polyacrylamide gel is an ideal materi-al for blood clots .