Changes and significance of antioxidant enzymes in plasma of tremor-dominant type and postural instability/gait difficulty type of Parkinson's disease
ZHOU Hong
ZHANG Ke-zhong
YUAN Yong-sheng
TONG Qing
QI Zhi-qiang
Abstract：Objective To investigate the changes and clinical significance of antioxidant enzymes in tremor -dominant type and postural instability/gait difficulty type of Parkinson's disease ( PD) patients.Methods Thirty-one PD patients were involved as the PD group , including sixteen PD patients of tremor-dominant type ( TDT) and fifteen PD patients of postural instability/gait difficulty type ( PIGDT) .Eighteen healthy subjects were used in the control group .Plasma levels of catalase ( CAT) , superoxide dismutase ( SOD) and glutathione peroxidase ( GSH-PX) were measured by ELISA .We ana-lyzed the correlation between plasma levels of the antioxidant enzymes and PIGD scores .Results Plasma levels of CAT and SOD in the PD group were significantly lower than those of the control group (P<0.01), and plasma levels of CAT and SOD in PIGDT PD were significantly lower than those of TDT PD (P<0.01).The plasma levels of CAT and SOD in PD patients were negatively correlated with PIGD scores (r=-0.623 and -0.438, respectively, all P<0.01).Plasma levels of GSH-PX had no significant difference in the two groups .Conclusions Antioxidant enzyme system is damaged in PD patients and badly damaged in PIGD PD patients .Plasma levels of CAT and SOD are decreased in PIGD PD patients , which may be closely related to its onset and severity .
Keywords：Parkinson's diseasetremor-dominant typegait difficulty typeantioxidant enzyme system
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 21-23 )