Expression of EphA2, E-cadherin in renal cell carcinoma and its relationship with clinical pathological features of patients
ZHANG Jun-xia
XU Jin-sheng
BAI Ya-ling
Cui Li-wen
ZHANG Hui-ran
ZHANG Sheng-lei
Abstract：Objective To investigate the expression of Eph receptor tyrosine kinase-A2 (EphA2) and E-cadherin in renal cell carcinoma ( RCC) and its relationship with clinical pathological features of patients .Methods The expression of EphA2 and E-cadherin was detected by immunohistochemical SP method in the tumor tissues from 52 RCC patients .The HSCORE score and percentage of positively stained cells were calculated .The relationships between the expression of E-phA2 and E-cadherin and clinical characteristics including age , gender , TNM classification , diameter of the tumor and pathologic types were analyzed .The three-year survival rate was calculated with the Kaplan-Meier method and compared by the Log-rank test.The main risk factors were screened by Cox hazard regression model .Results The percentage of pa-tients with high expression of EphA2 was 71.2%, and the percentage of patients with low expression of E-cadherin was 76.9%.The high expression rate of EphA 2 in patients with a tumor diameter ≥5 cm was higher than those with a tumor diameter <5 cm (P<0.05), and the low expression rate of E-cadherin in patients with a tumor diameter ≥5 cm was higher than those with a tumor diameter <5 cm (P<0.05).The high expression of EphA2 was a risk factor for the out-come of RCC patients (P<0.05).Conclusion The expression of EphA2 was increased, and the expression of E-cadher-in was decreased in the RCC tissue .The high expression of EphA 2 was the an independent risk factor for the prognosis of RCC patients .
Keywords：kidney neoplasmskidney carcinomaEph receptor tyrosine kinase-A2E-cadherinprognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )