Relationships of serum ferritin level, degree of liver inflammation and types in patients with liver disease
ZHAO Jing-jing
LI Jia
LIU Jie
MA Hai-xia
WU Ting
Abstract：Objective To analyze the relationships of serum ferritin ( SF) level, degree of Liver inflammation and types in patients with liver disease.Methods Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin ( ALB) ( by automatic biochemical analyzer ) and SF ( by immune turbidimetry ) , serum iron ( SI ) ( by complex legal) were detected and analyzed in 203 hospital patients of acute or chronic liver injury , whose SF were higher than nor-mal.The correlations between SF , SI and indicators of liver inflammation were analyzed as wel as the changes of SF and SI in patients with different liver cancer types and pathological degrees .Results Positively correlation was detected between the SF, SI and the ALT, AST (all P<0.01).SF was negatively correlated with ALB (P<0.01).The degree of elevated SF was the order of HEV infection , drug-induced hepatitis, HBV infection and HCV infection (χ2 =13.551, P<0.01) in different etiology , and meanwhile , ALT and AST followed the same order .The SI levels showed no statistical significance in different etiology(P>0.05).The levels of serum ferritin in acute hepatitis and liver failure patients were significantly higher than those in chronic hepatitis , liver cirrhosis and hepatocellular carcinoma .SI level was the lowest in hepatocellular carcinoma, and the difference in the remaining four groups performed no statistical significance (P>0.05).Conclusions SF is positively correlated with indicators of liver inflammation ( ALT, AST) .In patients with hepatitis C and liver fail-ure, SF can evaluate liver function more objectively and accurately than ALT and AST in clinical .
Keywords：liver diseasesliver inflammationserum ferritinserum iron
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 21-23 )