Changes and significance of NAA/Cho in transverse temporal gyri of type 2 diabetic patients with hearing impairment
SONG Dong-mei
LU Xin
LIU Tao
XU Ying-xia
WANG Bao-shan
Abstract：Objective To investigate the changes and significant of N-acetylaspartate/choline ( NAA/Cho ) in trans-verse temporal gyri of type 2 diabetic patients with sensorineural hearing loss .Methods Eighty-seven cases of patients with type 2 diabetes mellitus were selected .After the pure tone audiometry screening , they were divided into bilateral deafness group (25 cases), unilateral deafness group (22 cases) and diabetic group (40 cases), meanwhile, seventeen cases of nor-mal healthy volunteers were selected as the control group .All the above groups underwent bilateral transverse temporal gyri hydrogen magnetic resonance spectroscopy (1H-MRS) detection.Then the area under the peak NAA/Cho based on neural me-tabolites was calculated , and the difference between each group was compared;Pearson statistics was used for the analysis of correlation between blood glucose and neural metabolism;ROC curve area >50%was taken as the determination of index in diagnosis of early diabetes mellitus sensorineural hearing loss of sensitivity and specificity .Results Fasting blood glucose levels in diabetic patients were negatively correlated with NAA /Cho (r=-0.547, P<0.05).Compared with the control group, the NAA/Cho in the auditory cortex of affected and contralateral sides of bilateral deafness group , unilateral deafness group and diabetic group all decreased (all P<0.05);in the unilateral deafness group , NAA/Cho in the affected side de-creased as compared with the healthy side (P<0.05);when the NAA/Cho was 1.65, the sensitivity and specificity in diag-nosis of sensorineural deafness were 100%and 88%, respectively;and the ROC curve was 76%.Conclusion NAA/Cho was decreased in the transverse temporal gyri of pure diabetic patients , and the decrease was more significant in the diabetic patients accompanied by nerve deafness .NAA/Cho may be used as the early warning indicators of sensorineural deafness .
Keywords：type 2 diabetes mellitussensorineural deafnessN-acetylaspartatecholinehydrogen magnetic reso-nance spectroscopy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 9-11 )