Clinical significance of β-CTX and PINP alteration in lung cancer patients with bone metastasis treated with radiotherapy
PAN Xing-xi
YANG Wen
YANG Hua
TANG Wu-bing
Chen Yong-fa
ZHANG Yong-sheng
CHEN Zhi-ming
Abstract：Objective To investigate the clinical significance of βisomer of C-terminal telopeptide (β-CTX) and a-mino-terminal propeptide of type I collagen ( PINP) in lung cancer patients with bone metastasis before and after radiothera-py.Methods A total of 28 lung cancer patients with bone metastasis were enrolled in this study .Serumβ-CTX and PINP were measured before and after radiotherapy .The relationship between the level of serum β-CTX, PINP before and after ra-diotherapy and the response to radiotherapy were analyzed .Results 9 cases had complete remission of pain after radiother-apy, 10 cases partial remission, 9 cases no remission, the effective rate was 67.86%.Compared with pre-radiotherapy, the levels of β-CTX and PINP deceased after radiotherapy (both P<0.05).For radiotherapy responding group , the levels ofβ-CTX and PINP decreased after radiotherapy (both P<0.05).For radiotherapy non-responding group, the level of PINP decreased (P<0.05), while β-CTX slightly decreased (P>0.05).Conclusions The levels of β-CTX and PINP in serum of lung cancer patients with bone metastasis measurement after radiotherapy decreased compare with before radio -therapy, which might be as valuable index to monitor radiotherapy response .
Keywords：lung cancerbone metastasisβisomer of C-terminal telopeptideamino-terminal propeptide of type I collagenradiotherapy response
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 31-33 )