Correlation of cardiac function and brain natriuretic peptide before and after transcatheter closure of atrial septal defect in adults
ZHAO Yun
HAN Xiu-min
ZHU Xian-yang
SHENG Xiao-tang
GENG Jing-song
Abstract：Objective To observe the changes of cardiac function before and after transcatheter closure of atrial septal defect (ASD) in adults and the correlation between cardiac function and brain natriuretic peptide (BNP).Methods 47 adult ASD patients were enrolled.The diameter of ASD (Echcardiography), cardiac function and BNP in plasma (ELISA) were detected 1 day before occlusion and 72 hours after occlusion.Results Compared with pre-operation, RVEDd, 72 hours after transcatheter closure of RAD and TAPSE decreased significantly (all P<0.01), while LVEDd, LVEDV, LVSV and E/Em increased significantly (all P<0.01), BNP in plasma also increased significantly (P<0.01).Before transcathe-ter closure of logBNP was positively correlated with the size of ASD and the age of patients (both P<0.01).After tran-scatheter closure of logBNP was positively correlated with the size of ASD , RVEDd before operation , and E/Em 1 week af-ter the occlusion (all P<0.05).Conclusions Although there is no significant change in the left ventricular systolic func-tion, the left ventricular diastolic function damage often occurs transcatheter closure of ASD. BNP in plasma and the left ventricular diastolic function has positive correlation after the occlusion. BNP can be used as predictor of left ventricular di-astolic dysfunction in normal LVEF , in which preconditioning treatment is recommended before the occlusion to reduce postoperative complications.
Keywords：atrial septal defectocclusioncardiac functionbrain natriuretic peptideadult
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )