Effect of local 5-hydroxytryptamine on neuronal excitability of rat hypoglossal nucleus
WANG Wei
WANG Guang-fa
HU Xi-wei
Abstract：Objective To observe the effect of local 5-hydroxytryptamine (5-HT) on neuronal excitability of rat hypo-glossal nucleus .Methods Eight adult male SD rats were selected .Micro dialysis catheter was placed into the hypoglossal nucleus, through which, we pumped the fresh artificial cerebrospinal fluid (ACSF), fresh 5-HT solution into the hypoglos-sal nucleus .Then we monitored genioglossus electromyography at the moment of no drug delivery , pumping fresh ACSF , and pumping fresh 5-HT solution .The genioglossus electromyography area was calculated by interval measurement method . Results The genioglossus electromyography chin area at the time of no medicine administration , pumping ACSF , and pumping into 5-HT was respectively (0.811 ±0.122), (0.859 ±0.121), (1.247 ±0.122) mV· s, when we compared the former two, P=0.081;when we compared the first two with the latter two , P=0.003, 0.005.Conclusion 5-HT can improve the excitability of hypoglossal nucleus .
Keywords：5-hydroxytryptamineSD ratshypoglossal nucleusgenioglossus electromyography
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )