Effect of ischemic postconditioning on kidney ischemia-reperfusion injury and the expression of TNF-αin obstructive jaundice rats
LI Yi
ZHANG Xue-xia
JIA Ying-bin
LI Wen-hua
ZHANG Bai-meng
Abstract：Objective To investigate effect of ischemic postconditioning on kidney ischemia-reperfusion injury and the expression of TNF-αin obstructive jaundice rats .Methods Totally 60 SD rats were randomly divided into three groups ( n=20):obstructive jaundice group (group S), obstructive jaundice renal Ischemia-reperfusion group( group I/R), ob-structive jaundice +ischemic postconditioning group ( group IPO ) .According to the time of ischemia reperfusion , each group was divided into four subgroups (n=5):0 h reperfusion (T0), 1 h reperfusion (T1), 3 h reperfusion (T2), 6 h reperfusion (T3) .In each period, the serum urea of nitrogen (BUN), creatinine (Cr) and TNF-αwere collected and ob-served, kidney pathological changes were observed .Results Compared with group S, the serum levels of BUN and Cr in-creased, TNF-αin renal tissue were upregulated in groups I/R and IPO (all P<0.05).At T2, compared with group I/R, the serum levels of BUN, Cr and TNF-αdecreased (all P<0.05).Conclusions Ischemic postconditioning can downreg-ulate the expression of TNF-αand alleviate the renal ischemia-reperfusion injury in obstructive jaundice rats , whith may be through inhibiting inflammatory reactions .
Keywords：ischemic postconditioningischemia reperfusion injurykidneyobstructive jaundicetumor necrosis fac-tor-αrats
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )