Diagnostic value of G/GM assay for invasive fungal infections in pediatric patients with hematological malignancies
LI Tai-jie
LI Meng
GUO Shi-hui
LIANG Hong-jie
LI Shan
QIN Xue
LIU Zhi-ming
Abstract：Objective To evaluate the diagnostic value of serum (1, 3) -β-D-glucan (G assay) and galactomannan (GM assay) for invasive fungal infections in pediatric patients with hematological malignancies .Methods Totally 246 pe-diatric patients with hematological malignancies were selected to our study .According to invasive fungal infections diagnos-tic criteria, they were divided into two groups:infection group (n=27), non-infected group(n=219).The concentration of serum (1, 3) -β-D-glucan and galactomannan was detected by kinetic turbidimetric limulus test and ELISA .The sensi-tivity, specificity, positive predictive value and negative predictive value of GM test and G test and the combination of GM and G tests were calculated in diagnosing IFI .Results The sensitivity, specificity, positive predictive value and negative predictive values of G assay for the diagnosis of pediatric patients with invasive fungal infections were 88.89%, 91.78%, 57.14%and 98.53%, respectively; GM assay results were 66.67%, 71.23%, 22.22% and 94.55%, respectively;The results of G assay with GM assay using parallel analysis were 100%, 65.75%, 26.47%%and 100%, respectively;Using series analysis were 55.56%, 97.26%, 71.43%and 94.67%, respectively.Conclusions The G assay and GM assay were both useful in diagnosis of invasive fungal infections in pediatric patients with hematological malignancies .Using series analysis of G assay and GM assay can improve diagnostic specificity and positive predictive value .
Keywords：hematological malignanciespediatricinvasive fungal infections(13)-β-D-glucangalactomannan
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )