Diagnostic value of combining detection of PSA and PSAD in patients with prostate cancer bone metastasis
LIU Yan
XU Yong
LIU Ran-lu
ZHANG Zhi-hong
YANG Kuo
Abstract：Objective To investigate the clinical value of PSA , PSAS on prostate cancer with bone metastasis .Meth-ods A total of 238(a group of 112 cases of bone metastasis, a group of 126 cases of non-bone metastasis) patients with his-tologically diagnosed prostate cancer were analyzed .ECT, X-ray, CT and MRI were used to diagnose bone metastasis .Rela-tion among serum PSA and PSAD joint detection and bone metastasis were analyzed .Results According to serum PSA>20 ng/mL diagnostic criteria of bone metastasis , the rate of bone metastasis had significant difference between the two groups ( P<0.05), the sensitivity and specificity were 76.79%and 82.54%, respectively.According to serum PSAD>0.40 ng/(mL · cm3 ) diagnostic oriteria of bone metastasis , the rate of bone metastasis had significant differenc between the two groups ( P<0.05), the sensitivity and specificity were 82.14% and 75.40%, respectively.The sensitivity and specificity of serum PSA+PSAD were 82.14% and 84.13%, respectively .Using ROC curve to determine the diagnosis critical value of PCa bone metastases, the best critical value of serum PSA was 20 ng/mL and the best critical value of serum PSAD both 0.40 ng/( mL· cm3 ) .Conclusions Serum PSA and PSAD are both valuable parameters used in prediction of PCa bone metastasis . Serum PSA and PSAD joint detection can be better to help doctor predicting PCa bone metastasis .
Keywords：prostate cancerbone metastasisprostate specific antigenprostate specific antigen density
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-3,6 )