Effects of pontine pneumotaxic center on hypoxia respiratory response
WANG Hui
YANG Jun-qing
HUAI Rui-tuo
Abstract：Objective To investigate the role of NMDA and GABA receptors located in pontine pneumotaxic center neurons in peripheral chemoreflex .Methods Experments were done on rats to observe the effects of NMDA receptor an-tagonist D-2-amino-5-phosphonovaleric acid ( D-AP5 ) and GABA receptor antagonist bicuculline ( BIC ) on the phrenic nerve discharges in peripheral chemoreflex by microinjecting the two antagonists into pontine .Results The post-hypoxic frequency decline ( PHFD ) was attenuated after microinjection of D-AP5 while the acute hypoxia response was not in-flunced.The rapid increase in respiratory frequency and the parallel shortening of expiratory time were enhanced after mi -croinjection of BIC , while PHFD was not influenced .Conculsion Neurotransmissions mediated by NMDA and GABA re-ceptors mainly modulate PHFD and the acute hypoxia response respectively .
Keywords：receptorNMDAGABApontine pneumotaxic centerhypoxia respiratory responserat
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-20 )