Significance of transverse temporal gyrus NAA/Cho in obstructive patients with hearing loss
SONG Dong-mei
LV Xin
LIU Tao
WANG Bao-shan
Abstract：Objective To explore the changes of NAA/Cho in transverse temporal gyrus with 1 H-MRS in obstructive sleep apnea hypopnea syndrome ( OSAHS) patients for looking for early warning indicators of hearing damage .Methods 80 patients with OSAHS confirmed by PSG were divided into bilateral deafness group (n =26), unilateral deafness group(n =15) and simple OSAHS group (n =39); 19 healthy volunteers were as normal control group .1 H-MRS was used todetect NAA/Cho in transverse temporal gyrus of the above groups , then compared with each group; the area under ROCcurve of >50% was used to judge the specificity and sensitivity of NAA /Cho as early tips for OSAHS patients with sensorineuralhearing loss.Results Compared with normal control group, OSAHS with (bilateral and unilateral) deafness groupsauditory cortex NAA/Cho decreased (all P <0.05); compared with the simple OSAHS group, OSAHS groups with (bilateraland unilateral) deafness NAA /Cho also decreased (all P <0.05); while there was no significant difference betweenipsilateral and contralateral transverse temporal gyrus in unilateral deafness OSAHS group (P >0.05).The area of NAA/Cho under the ROC curve was 78%.Conclusion In transverse temporal gyrus, nerve metabolites cortex NAA /Cho mayserve as early warning indicator to prompt OSAHS patients with sensorineural hearing damage occur .
Keywords：obstructive sleep apnea hypopnea syndromeN-acetyl aspartate/cholinesensorineural hearing loss1 H magnetic resonance spectroscopy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )