Influence of asymptomatic hyperuricemia on male kidney function
LI Ling-qin
QING Yu-feng
ZHOU Chang
ZHOU Jing-guo
Abstract：Objective To investigate the effects of asymptomatic hyperuricemia ( HUA ) on male kidney function . Methods 252 male patients with asymptomatic HUA ( HUA group ) and 157 healthy male cases with normal blood uric acid ( NUA group ) conducted a questionnaire survey , physical examination , serum creatinine ( Scr ) and urea nitrogen (BUN) were measured.Calculation of glomerular filtration rate (eGFR) according to MDRD, to compare renal function between two groups .Results Compared with NUA group , the eGFR was lower and Scr was higher in HUA group ( both P<0.05).There were significant differences in eGFR, Scr and BUN in different age groups in HUA group (eGFR: F=10.939, P=0.000;Scr:F=2.848, P=0.025;BUN:F=4.419, P=0.002).In NUA group, the eGFR in the 65-79 age cases was significantly lower than that of 21-30 age and 31-40 age cases (F=2.587, P=0.039);Scr and BUN were no significant differences in different age cases .The rate of declining renal function in HUA group was significantly higher than that in NUA group (P<0.05).Conclusions The risk of declining renal function in male asymptomatic hyperurice-mia patients increases with time-dependent manner .For asymptomatic hyperuricemia patients , it may be necessary to take effective measures to control the blood uric acid level to reduce its effect on renal function .
Keywords：hyperuricemiaserum creatinineglomerular filtration raterenal functionmale
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )