Concentration change of human C reactive protein in the serum of typeⅡdiabetes mellitus patients with macroangiopathy and its clinical significance

doi:10.3969/j.issn.1002-266X.2015.03.006

Abstract：Objective To investigate the level change of serum hypersensitive c-reactive protein ( hs-CRP) and its sig-nificance in type 2 diabetes mellitus (T2DM) patients with vascular lesions.Methods Selection of 45 patients with T2DM combined large vascular lesions (group A) and 45 cases of pure T2DM patients (group B) and 40 cases of healthy physical examination ( group C) , with transmission turbidimetric method to detect serum hs-CRP, using automatic biochemistry ana-lyzer determination of blood lipid , micro column method was used to measure blood sugar .The relationship among the ser-um hs-CRP and blood glucose , blood lipid in group A was performed by Pearson correlation analysis .Results The serum hs-CRP in group A, B, C was(4.12 ±2.15), (2.16 ±0.92), (0.62 ±0.34) ng/mL, glycosylated hemoglobin (HbA1c) was 11.09%±1.67%, 9.27%±1.21%, 4.17%±0.41%, fasting blood glucose (FPG) was (11.86 ± 3.91), (10.97 ±3.36), (4.58 ±0.76)mmol/L, postprandial 2 hours blood glucose (PPG) was (15.91 ±2.34), (13.79 ±3.29), (6.16 ±0.83)mmol/L.Comparison of serum hs-CRP among the three groups, P<0.01.Group A and group B compared with group C of HbA1c, FPG, PPG, P<0.01.The level of TC in group A, B, C was(5.84 ±0.56), (5.47 ±0.34), (3.31 ±0.25)mmol/L, TG was (2.27 ±0.27), (2.18 ±0.23), (1.21 ±0.19)mmol/L, LDL-C was (4.46 ±0.91), (4.34 ±0.67), (2.07 ±0.31)mmol/L, HDL-C was(1.17 ±0.37), (1.21 ±0.42), (1.51 ±0.62) mmol/L, the level of TC, TG, LDL-C, HDL-C in group A, B compared with group C, P<0.01.Correlation analysis re-sults showed that serum hs-CRP and HbA1c , FPG, PPG, TC, TG, LDL-C were positively correlated ( r were 0.368 5, 0.439 3, 0.384 7, 0.306 9, 0.343 1, 0.404 5, P<0.01), and negatively correlated with HDL-C (r=0.239 3, P<0.01).Conclusion The level of serum hs-CRP increase significantly in T2DM patients with vascular lesions .The hs-CRP may participate in the T2DM of the pathological process of vascular lesions .