Predictive value of the Level of Plasma Fibrinogen for the Outcome of Patients with Transient Ischemic Attack

ZHAO Zhen-qiang; HU Lan; CAI Mei-hua; CHEN Zhi-bin; WANG Shu-rong; WANG Tan

doi:10.3969/j.issn.1002-266X.2015.03.004

Abstract：Objective To explore the predictive value of the level of plasma fibrinogen ( FIB ) for the prognosis of pa-tients with transient ischemic attack ( TIA) .Methods 132 patients with acute TIA in hospitalization were enrolled .These patients were divided into low (0~3 points, 46 patients), mederate (4~5 points, 70 patients) and high (6~7 points, 16 patients) risk groups according to their ABCD2 scores.The levels of FIB were detected by using SYSTEX CA-7000 Au-tomated Blood Coagulation Analyzer .The primary outcome measure was a composite endpoint consisting of stroke or death within 90 days;≥50%stenosis in a artery association with clinical symptoms or cardioembolic source warranting anticoagu -lation.Results The composite end point occurred in 34 patients ( positive group ) and was not found in other 98 patients ( negative group ).The level of FIB was higher in positive group compared to negative group [(4.53 ±0.99) vs (3.05 ± 0.93)g/L, P<0.05].There was significant difference among low-risk, mederate-risk and high-risk groups in the levels of plasma FIB [(2.98 ±0.86) vs (3.54 ±1.47) vs (5.16 ±1.68)g/L, P<0.05].Spearman rank correlation coefficient test showed that the level of plasma FIB was positively correlated with ABCD 2 score (r=0.388, P<0.001).Cox regres-sion analysis showed that ABCD 2 score ≥4 and FIB≥3.5 g/L were significantly associated with the composite endpoint . Conclusion The level of plasma FIB significantly increase in TIA patients with positive composite endpoint , and is posi-tively correlated with ABCD2 score.Using the threshold value of 3.5 g/L for FIB, there was a trend toward FIB predicting outcome of these patients within 90 days after TIA .