Expression and significance of NF-kappa B, MMP-9, MICA in pituitary adenoma tissues
CHEN Zheng
CHANG Ying-wei
LI Zhen-zhu
SUN Qi-kai
WANG Qing-bo
LI Ze-fu
Abstract：Objective The aim of this study was to examine the expression levels of NF-κB, MMP-9, and MICA and to explore its significance .Methods We examined the association between NF-κB, MMP-9, and MICA by immunohisto-chemical staining, Quantitative real-time PCR.Results The positive rate of NF-κB were 100%(40/40), 30%(6/20)in pituitary adenomas and normal brain tissue .The positive rate of MMP-9 were 100%(40/40),15%(3/20)in pituitary ade-nomas and normal brain tissue .The positive rate of MICA were 100%(40/40), 0 in pituitary adenomas and normal brain tissues(P<0.05).Relative to express the NF-κB mRNA were 13.045 ±6.2, 2.04 ±2.067 in pituitary adenomas and normal brain tissues.Relative to express the MMP-9 mRNA were 28.77 ±7.661, 2.369 ±1.46 in pituitary adenomas and normal brain tissues.Relative to express the MICA mRNA were 231.817 ±41.046, 5.062 ±3.849 in pituitary adenomas and normal brain tissues(P<0.05).The expression levels of NF-κB, MMP-9, and MICA were positively related in pa-tients with pituitary adenomas (r=0.368,0.345,P<0.05).Conclusions NF-κB, MMP-9, and MICA are highly ex-pressed in pituitary adenomas tissues .High levels of NF-κB by promoting the expression of MMP-9 and MICA promote the development of pituitary adenomas .
Keywords：Pituitary adenomasMHC-Ⅰkind of chain molecules related antigen Amatrix metalloproteinase 9nu-clear transcription-κB
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )