Relationship among irisin, diabetic nephropathy and it′s clinical metabolic parameters
YANG Mei-li
CHEN Pei-hong
JIN Hua
XIE Xin-miao
GAO Ting
YANG Li-li
YU Xue-mei
Abstract：Objective To investigated the association among serum irisin level , diabetic nephropathy ( DN) and it′s clinical metabolic parameters .Methods A total of 54 subjects with diagnosed type 2 diabetes were involved in this study , including 8 DN patients (DN group) and 46 normal glomerular filtration rate (GFR) patients (control group).Height , weight, body mass index (BMI), blood pressure, skeletal muscle, body fat mass, body fat percentage, blood glucose , se-rum lipid, hepatic function , kidney function and irisin level were measured .The association between serum irisin and met-abolic parameters was analyzed by Pearson bivariate correlation and multiple linear regression analysis .Results Compared with control group, the serum creatinine level of DN group increased and the irisin level decreased (P<0.05).Irisin level was positively correlated with HbA1C(r=0.269,P<0.05), GFR(r=0.327, P<0.05), systolic pressure(β=0.485, P<0.05), total cholesterol(β=1.737, P<0.05).Irisin level was negatively correlated with LDL-C(β=-1.370, P<0.05).Conclusions Serum irisin level was lower in DN patients , which indicated that irisin may be involved in the me-tabolism disorder of glucose and lipid as well as the kidney impairment of DN .
Keywords：diabetic nephropathyenergy metabolismirisin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )