Screening of proteins associated with pediatric bilateral wilms tumor
YAN Ze-chen
DAI Xing
YANG Jin-jian
ZHANG Jun-jie
GUO Fei
YU Jie-kai
ZHENG Shu
WANG Jia-xiang
Abstract：Objective To select the differentially expressed proteins of bilateral wilms tumor (BWT) by using SELDI-TOF-MS technology .Methods A total of 10 serum samples of children with BWT ( BWT group ) , 20 serum samples of children with Unilateral Wilms Tumor ( UWT group ) and 20 serum samples of healthy children ( control group ) were select-ed.SELDI-TOF-MS technology was used to detect the differentially expressed BWT proteins .Results Ten difference BWT proteins peaks were found(P<0.01).The highest Youden′s index was obtained to select one differentially expressed protein with m/z of 5 648 Da.The selected expression BWT protein in BWT group , UWT group and control group was 3 889.36 ±1 796.83, 2 886.81 ±1 404.65 and 432.21 ±730.42, respectively(all P<0.01).Conclusion A differen-tially expressed protein of BWT group was successfully obtained by using SELDI-TOF-MS technology , which is expected to be a new marker for the early diagnosis and prognosis of BWT .
Keywords：bological markersnephroblastomaproteomics
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )