Application of FibroScan in diagnosis of liver fibrosis in patients with chronic hepatitis B
XU Yan
FENG Yan-ling
SHI Yu-xin
Abstract：Objective To explore the application value of transient elastography (FibroScan) in the diagnosis of liver fibrosis of chronic hepatitis B ( CHB) .Methods A total of 165 patients diagnosed with chronic hepatitis B were involved in the study, including 77 mild fibrosis patients, 47 moderate fibrosis patients, 41 severe fibrosis and cirrhosis patients .In addition, 50 subjects were selected as control group .FibroScan was used for measurement of liver stiffness measurement (LSM).Patient group were subjected to blood platelet , aspartate aminotransferase(AST), glutamyl transpeptidase (GGT) and cholesterol detection by normal and clinical biochemical test , and then APRI and Forns were caculated .The receive operating characteristic ( ROC) curve was adopted to analyze the accuracy of transient elastography alone and combination of APRI、Forns for the detection of liver fibrosis .Results In the diagnosis of moderate fibrosis , the AUC were 0.807, 0.786, 0.767 respectively, the cutoff value were 8.5, 8.1, 11.7 respectively, the sensitivity were 83.3%, 60.0%, 73.3%respectively, the specificity were 81.6%, 92.1%, 76.3%respectively.In the diagnosis of severe fibrosis and cir-rhosis, the AUC of FS, Forns, APRI were 0.896, 0.886, 0.829 respectively, the cutoff value were 16.3, 8.4, 9.3 re-spectively;the sensitivity were 73.3%, 80.0%, 73.3%respectively, the specificity were 90.6%, 83.0%, 88.7% re-spectively.In the diagnosis of moderate fibrosis , the AUC of FS +APRI +Frons, S+Frons, FS +APRI and FS were 0.851, 0.832, 0.826, 0.807 respectively, the sensitivity were 66.7%, 76.7%, 70.0%, 83.3%respectively, the spe-cificity were 97.4%, 81.6%, 89.5%, 81.6%respectively.In the diagnosis of severe fibrosis and cirrhosis , the AUC of FS+APRI+Frons, FS+Frons, FS+APRI and FS were 0.922, 0.904, 0.907, 0.896 respectively;the sensitivity were 86.7%, 86.7%, 80.0%, 73.3%respectively;the specificity were 88.7%, 83%, 88.7%, 90.6%respectively.Con-clusions The diagnosis of liver fibrosis of chronic hepatitis B by FibroScan has high accuracy .When the hematic-biochem-ical index is combined the diagnosibility of combined detection is stronger .FibroScan and combined diagnosis are valuable for clinic application .
Keywords：chronic hepatitis Bliver fibrosisFibroScancombined diagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 21-24 )