Association of Insulin-like growth factor-I with reactive oxygen species in seminal plasma and semen quality among obesity and overweight infertile male
BAI Shuang-yong
WANG Jian-song
MENG Yu-shi
Abstract：Objective To observe the change of insulin-like growth factor 1 ( IGF-1 ) and reactive oxygen species ( ROS) levels in the seminal plasma of overweight and obese patients with infertility , and to explore its clinical signifi-cance.Methods 227 male patients were randomly selected .They were divided into normal fertile group (58 cases who had normal weight and one or more children ), normal infertility group(50 cases who had normal weight but nfertility ), o-verweigh infertility group(60 cases who had overweight and nfertility ) and obese infertility group(59 cases who were obese and nfertility).Semen specimen was performed by conventional analysis .The levels of seminal plasma IGF-1 and ROS were detected by ELISA .Results Compared with normal fertile group , the level of IGF-1 in seminal plasma of normal in-fertility group decreased (all P<0.05).Compared with normal fertile group and normal infertility group , the levels of IGF-1 and ROS in seminal plasma of obese infertility group and overweight infertility group increased (all P<0.05).Com-pared with overweight infertility group, the levels of IGF-1 and ROS in obese infertility group increased(all P<0.05).In all the male infertility patients, BMI had negative correlation with sperm volume (B=0.17, P<0.05), positive correlation with sperm malformation rate(B=0.20, P<0.05), positive correlation with IGF-1(B=0.285, P<0.05), and positive correlation with ROS(B=0.414, P<0.05).ROS and IGF-1 were positively correlated(B=0.619, P<0.05).IGF-1 and sperm forward movement rate were positively correlated (B=0.150, P<0.05).Conclusions The level of IGF-1 in seminal plasma decrease in patients with normal body mass and infertility .The levels of ROS and IGF-1 rise in overweight and obese patients with infertility .The above indicators can help to analyze the infertility effect of overweight and obesity and provide reference for clinical treatment .
Keywords：body mass indexinsulin-like growth factor-Ireactive oxygen speciesobesityinfertility
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )