Effect of NB-UVB combined with compound glycyrrhizin on alopecia areata
LI Ling
SUN Ji-rui
ZHANG Guo-qiang
ZHANG Nan
HU Jue-ning
LI Hai-yan
Abstract：Objective To investigate the therapeutic effect and mechanism of narrow-band ultraviolet ( NB-UVB ) combined with compound glycyrrhizin in the treatment of alopecia areata .Methods A total of 73 patients with alopecia areata were randomly divided into the drug treatment group (37 patients) and the combined treatment group (36 patients). A total of 37 patients were selected as health control group who did health examination in the same time .The drug treatment group and the combined treatment group were given oral compound glycyrrhizin at 50 mg, 3 times/d.The combined treat-ment group was given NB-UVB radiation therapy besides the oral compound glycyrrhizin .The treatment effectiveness for both groups was evaluated after 3 months.The change of the CD 3+, CD4+and CD4+/CD8+cellular level in peripheral blood was measured by flow cytometry before and after treatment .Results The effective rate of combined treatment group and drug treatment group was 91 .9%and 71 .2%, respectively .The effective rate of combined treatment group was higher than that of drug treatment group ( P<0 .05 ) .Before treatment , compared with the health control group , the cellular level of CD3+, CD4+and CD4+/CD8+of the combine group and the drug treatment group was significantly lower (P<0.05).After treatment , the cellular level of CD 3+, CD4+and CD4+/CD8+of both the combine group and the drug treatment group was sig-nificant higher than before treatment (P<0.05).However, CD8+level was no significant changed in combine group and drug treatment group before and after treatment .The change of cellular level of CD 3+, CD4+and CD4+/CD8+of the combine group was significantly higher than drug treatment group (P<0.05).However, CD8+level was no significant changed in combine group before and after treatment .Conclusions The dysfunction of immune system exists in patients with alopecia areata .NB-UVB combined with glycyrrhizin to treat alopecia areata proved to have a significant curative effect .The mecha-nism of NB-UVB radiation therapy might be able to improve the immunity of alopecia areata patients .
Keywords：alopecia areatanarrow-band ultravioletcompound glycyrrhizinTlymphocyte subsets
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 33-35 )