Expression and clinical significance of Caspase-9, Bcl-2 and bax in basal-like breast carcinoma
ZHANG Bing-xin
ZHAO Xia
CHEN Xue
CHANG Wen-long
ZHANG Jin-ku
Abstract：Objective To investigate the expression of Caspase-9, bcl-2 and bax in basal-like breast carcinoma ( BLBC) and their role in carcinogenesis and progression of BLBC .Methods The immunohistochemistry method was used to detect the expression of Caspase-9, bcl-2 and bax in 43 cases of BLBC,57 cases of non-BLBC and 60 cases of normal breast tissue.The correlationship and relationship of Caspase-9, bcl-2 and bax with clinicopathological features were ana-lyzed.Results The positive rate of bcl-2 in BLBC and non-BLBC was higher and the positive rate of Caspase-9 and bax was lower than that in normal breast tissue (P<0.05).The expressions of Caspase-9, bcl-2 and bax were not correlated with the age of patients and the size of tumor .The expressions of Caspase-9, bcl-2 and bax were correlated with lymphnodes metastasis and pTNM staging of BLBC (P<0.05).The expression of Caspase-9 was positive correlated with bax (r2 =0.572, P<0.05).The expression of Caspase-9 was negatively correlated with bcl-2(r=-0.381, P<0.01).The ex-pression of bax was negatively correlated with bcl-2 (r=-0.408, P<0.01).Conclusions The expressions of Caspase-9 and bax decreased and the bcl-2 was increased in BLBC.Caspase-9, bcl-2 and bax were jointly played a role in carcino-genesis and development of BLBC .
Keywords：basal-like breast cancerCaspase-9B-cell lymphoma/leukemia cell tumor-2bax
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )