Relationship between single nucleotide polymorphisms in UMOD gene promoter region and the age-onset of chronic disease kidney
BAI Ya-ling
XU Jin-sheng
ZHANG Wen-bo
ZHANG Sheng-lei
ZHANG Jun-xia
Cui Li-wen
Abstract：Objective To investigate the relationship between single nucleotide polymorphisms in UMOD gene pro -moter region and the age-onset of chronic kidney disease ( CKD ) .Methods A total of 89 CKD patients ( patient group ) and 104 healthy volunteers ( control group ) were involved in this study .PCR was used to detect the peripheral blood pro-moter region of UMOD gene .The relationship between the polymorphisms in UMOD gene promoter and the age-onset of chronic disease kidney was analyzed .The relationship between the age-onset of CKD and sex, age, smoking history, BMI, mean arterial pressure were analyzed .Results The sequence of -1 617(rs13333226)G polymorphisms in patient group was higher than that in control group (χ2 =4.737, P=0.030).The onset age of CKD patients with rs13333226A was sig-nificantly younger than that of patients with rs13333226G(χ2 =7.902, P=0.005).Single factor analysis showed that the age-onset of CKD patients with BMI >22 was earlier than those with BMI<22(P<0.05).The age-onset of CKD patients with smoking history was earlier than those without smoking history (P<0.05).The SNP of rs13333226 was the independ-ent risk factor for the the age-onset of CKD(OR=0.494,95%CI:0.268~0.913,P<0.05).Conclusions The frequen-cy of rs13333226 G allele was higher in CKD patients .The onset age of CKD patients with rs 13333226 A was significantly earlier.The SNP of rs13333226 was the independent risk factor for the the age-onset of CKD.
Keywords：UMODsinglenueleotide polymorphismchronic kidney diseaseage of onset
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 5-7 )