Relation between CD86 gene-3479 A/C site polymorphism and genetic susceptibility to primary immune thrombocytopenia
WU Pin
WANG Zhi
LU Shi-yun
ZHAO Xiao-hong
Abstract：Objective To explore the association between the CD 86 -3479 A/C site ( rs2715267 ) polymorphism and the risk of ITP.Methods Ninety three adult chronic ITP patients and 119 normal controls were enrolled in this study . Genomic DNA was extracted from peripheral blood , and genotyping of -3479 A/C site was performed by using a PCR with sequence specific primers and confirmed by DNA sequencing .Results CD86 gene -3479 A/C site genotype frequencies of AA, AC and CC were 40.9%, 52.6%and 6.5%in ITP patients respectively, and were 49.6%, 37.8%and 12.6%in normal controls respectively (P>0.05).The allele frequencies of A and C were 67.2%and 32.8%in ITP patients re-spectively, and were 68.5%and 31.5% in normal controls respectively(P>0.05).We further subdivided the patients and normal controls according to the sex and clinical responses to glucocorticoids , but still did not find any difference in genotype and allele frequencies between each pair of these subgroups .Conclusion CD86 -3479 A/C polymorphisms may not be associated with the genetic susceptibility to ITP in a Chinese population .
Keywords：thrombocytopeniaCD86polymorphismsingle nucleotide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 19-22 )