Effect of basic fibroblast growth factor on neovscularization in alkali burned rabbit corneas
GUO Li-yun
ZHANG Jie-ying
SUN heng
HU Zhu-lin
BIAN Hui
Abstract：Objective To investigate the effect of basic fibroblast growth factor ( bFGF) on the promotion of neovscu-larization in alkali burned rabbit corneas .Methods Establishing the alkali burned rabbit corneas models , and then dev-ided them into two groups .In the experimental group , bFGF was injected into conjunctiva of rabbits every week before lefe eye cornea transplantation , and then observing the formation of new blood vessels of cornea to evaluate the effect of bFGF on the neovscularization .The right eye of rabbit as the control group , only establishing the alkali burned rabbit corneas models and performing the implantations of keratoprothsis .Results The amount of neovascularization in the rabbit's corneas in ex-perimental group was larger than that in contral group statistically ,before or after implantation; The transplantated kerato-prothesis of experimental group grew well , there were no severe complications occurred such as meltage and perforation . Conclusions bFGF has a significant effect on promotion of neovascularization in alkali burned rabbit corneas and decrea -sing the inflammatory reaction .
Keywords：corneal diseasescorneal transplantationfibroblast growth factor 2rabbit
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )