Effects of repeated positive acceleration exposure and propafenone intervention on transmural dispersion of repolarization in ventricle muscle cells of rabbits
DUANMU Lu-jian
WANG Lan
JIAO Lin
LIU Bai-mei
SUN Hong-jiao
LI Yu-qian
YU Xin-ya
HUANG Cong-chun
WANG Jun-hua
LUO Hui-lan
WANG Jian-chang
Abstract：Objective To investigate the effects of repeated positive acceleration ( +Gz) exposure and propafenone intervention on transmural dispersion of repolarization ( TDR) in ventricle muscle cells of rabbits, to explore the cellular electrophysiologic mechanisms of arrhythmia induced by positive acceleration and the antagonistic mechanism of propafenone.Methods 30 male New Zealand white rabbits were randomly divided into control group, +Gz group and propafenone intervention group.The monophasic action potential ( MAP) recording technology used to record three layers of ventricular muscle cells MAP simultaneously, and to measue MAPD90 and TDR.Results Compared with the control group, the MAPD90 of endocardial and epicardial cells in +Gz group were decreased (all P<0.05), the left ventricle TDR was increased (P <0.05).Compared with the +Gz group, the MAPD90 of endocardial and epicardial cells in propafenone intervention group rabbbits were increased (all P<0.05), the left ventricle TDR was decreased (P<0.05). Conclusion The MAPD90 of ventricular muscle cells decrease and the TDR increase, maybe the cell electrophysiological mechanisms of arrhythmia induced by +Gz, and propafenone can antagonize this effect.
Keywords：positive accelerationarrhythmiapropafenonetransmural dispersion of repolarizationmonophasic ac-tion potentialrabbit
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 26-28 )